Which statement regarding Human papillomavirus (HPV) serotypes is true?

High-risk serotypes of Human papillomavirus (HPV) are indeed estimated to be responsible for approximately 99% of cervical precancerous lesions. These high-risk types, which include HPV 16 and 18, are primarily associated with the development of cervical cancer. They can lead to the transformation of normal cervical cells into precancerous cells by causing changes in the cell's DNA. This well-established link is why high-risk HPV types are a major focus of cancer prevention strategies, including vaccination and screening programs.

The other statements contain inaccuracies or misrepresentations of HPV. The virus is actually a DNA virus, not an RNA virus, and there are more than 200 known HPV types, encompassing both high-risk and low-risk variants. Among these, types 6 and 11 are recognized as low-risk serotypes and are primarily associated with benign conditions such as genital warts, not cervical cancer. Consequently, while recognizing high-risk types and their association with cervical cancer is critical for effective prevention efforts, the understanding of HPV's broader classification and transmission modes is equally important in managing and preventing HPV-related diseases.