Which over-the-counter medications are recommended to treat systemic reactions after vaccination?

The recommended over-the-counter medications to treat systemic reactions after vaccination are NSAIDs (non-steroidal anti-inflammatory drugs) and acetaminophen. These medications are effective in managing common systemic reactions such as fever, headaches, and muscle aches that may occur following vaccination.

NSAIDs, such as ibuprofen or naproxen, work by reducing inflammation and alleviating pain, while acetaminophen primarily addresses pain and fever. They are both well-tolerated options for individuals who experience mild to moderate symptoms after receiving a vaccine. Using these medications can help improve comfort levels following vaccination without interfering with the immune response to the vaccine, which is a critical consideration in vaccination practice.

Other options, while they may address specific symptoms, do not provide the comprehensive support recommended for managing systemic reactions. For example, using decongestants or antihistamines like cetirizine or diphenhydramine would not target the common post-vaccination symptoms effectively. Similarly, medications such as loperamide and bismuth subsalicylate are aimed at gastrointestinal issues rather than systemic reactions. Hence, NSAIDs and acetaminophen are the most suitable choices for this context.